Director, Penn Institute for Biomedical Informatics
Professor and Vice Chair of Faculty Professional Development
Department of Biostatistics, Epidemiology and Informatics
Associate Director for Quantitative Data Science, Abramson Cancer Center
Dr. Long’s research program marries innovative data science, informatics, and ML/AI research with impactful biomedical research. His lab has focused on developing robust statistical and ML/AI methods and models for advancing intelligent precision medicine and population health. Specifically, he has developed robust methods and models for integration of complex multimodal health data (such as -omics data, electronic health records data, and imaging data), missing data, causal inference, data privacy (federated learning and differential privacy), algorithmic fairness, and clinical trials. More recently, Dr. Long’s research has branched into LLMs, foundation models and agentic AI for biomedicine. Dr. Long’s methodological research has been supported by the National Institutes of Health (NIH), the Patient-Centered Outcomes Research Institute (PCORI), the National Science Foundation (NSF), and the Advanced Research Projects Agency for Health (ARPA-H).
Dr. Long has directed the Statistical and Data Coordinating Center for national research networks and large-scale multi-site clinical studies – supervising a team of database administrators and programmers, application developers and statistical analysts. He currently co-directs (with Dr. Nicola Mason at Penn Vet) the Coordinating Center for the Premedical Cancer Immunotherapy Network for Canine Trials (PRECINCT), part of NCI’s Cancer Moonshot Initiative, and co-directs (with Dr. Jesse Hsu) the Statistical and Data Coordinating Center for the Risk Underlying Rural Areas Longitudinal (RURAL) Cohort Study, funded by NIH/NHLBI.
Dr. Long also has a faculty appointment in the Department of Computer and Information Science at the School of Engineering and Applied Science and in the Department of Statistics and Data Science at Wharton. In addition, Dr. Long is the founding Director of the Center for Cancer Data Science, Associate Director for Cancer Informatics of the Penn Institute for Biomedical Informatics, and Associate Director for Quantitative Data Science of the Abramson Cancer Center at the University of Pennsylvania.
Dr. Long is an elected fellow of the American Association for the Advancement of Science (AAAS), the American Institute for Medical and Biological Engineering (AIMBE), the American Statistical Association (ASA), the Institute of Mathematical Statistics (IMS), the International Statistical Institute (ISI), and the American Medical Informatics Association (AMIA).
The Long Lab‘s mission is to advance responsible and trustworthy data science and AI for precision medicine.
Research areas: Robust statistical and machine learning methods for analysis of big, complex health data including -omics, electronic health records (EHRs), imaging data, and mobile health (mHealth) data; missing data; causal learning; Bayesian methods; clinical trials; data privacy; bias and fairness in AI for medicine; LLMs and Agentic AI for biomedicine