Center for Clinical Trials Innovation (CCTI)
An international research, training, and collaboration hub that will improve health through methodological advances in clinical trials.
Leadership
Michael Harhay, PhD, MPH
Associate Professor of Epidemiology, Medicine (Pulmonary and Critical Care), and Statistics and Data Science
About the Director
Dr. Harhay is an Associate Professor of Epidemiology, Medicine (Pulmonary and Critical Care), and Statistics and Data Science at the University of Pennsylvania. He also serves as the Founding Director of the Center for Clinical Trials Innovation and Co-Director of the Research Data and Analysis Core (RDAC) for Penn PORTAL.
Dr. Harhay specializes in the statistical design, analysis, and interpretation of large randomized trials and cohort studies. He has been involved in more than 20 randomized trials and has particular research interests in many of the most challenging topics in the design and analysis of contemporary trials, including (composite) outcome measure development and interpretation, methods for missing outcome data, health-system embedded and pragmatic cluster-randomized designs, Bayesian and adaptive trial methods, and applications of causal inference methods to augment the interpretation of randomized (experimental) data.
Our People
Primary Penn Faculty Collaborators
Scott D. Halpern, MD, PhD, M.Bioethics
John M. Eisenberg Professor of Medicine, Epidemiology, and Medical Ethics and Health Policy
Katherine Courtright, MD, MSHP
Assistant Professor of Medicine
Nadir Yehya, MD, MSCE
Attending Physician, CHOP
Associate Professor of Anesthesiology, Critical Care and Pediatrics
Dylan Small
Universal Furniture Professor
Professor and Chair, Department of Statistics and Data Science
The Wharton School
Todd A. Miano, PharmD, PhD
Assistant Professor of Epidemiology
M. Kit Delgado, MD, MS
Assistant Professor of Emergency Medicine and Epidemiology
Faculty Director of the Nudge Unit
J. Margo Brooks Carthon, PhD, RN, FAAN
Professor of Nursing and Africana Studies
Director, Barbara Bates Center for the Study of the History of Nursing
Penn Nursing
Core Team
Zhe Chen, PhD
Postdoctoral Researcher
Kenneth M. Lee, PhD
Postdoctoral Researcher
Yingying Lu, PhD, MBA
Biostatistician, Palliative and Advanced Illness Research (PAIR) Center
External Collaborators
Our work is strengthened by collaborations with clinical trialists and methodologists worldwide. Key collaborators include:
- Fan Li, PhD, Yale University
- Brennan Kahan, PhD, MRC Clinical Trials Unit at UCL
- Eddy Fan, MD, PhD, University of Toronto
- Ewan Goligher, MD, PhD, University of Toronto
- Anders Granholm, PhD, University of Copenhagen
- Anna Heath, MMath, PhD, The Hospital for Sick Children
- Matthieu Legrand, MD, PhD, University of California San Francisco
- Fernando Godinho Zampieri, MD, PhD, University of Alberta