An international research, training, and collaboration hub that will improve health through methodological advances in clinical trials.
Randomized clinical trials (RCTs) are widely regarded as the gold standard for evaluating healthcare interventions. Penn’s Center for Clinical Trials Innovation is dedicated to advancing trial methodology and implementing the latest innovations in trial design and analysis to support world-class and large-scale pragmatic RCTs at Penn Medicine and with external partners.
Our mission is to improve health by advancing the methodology of clinical trials. To accomplish this, we develop, evaluate, and implement innovations that enhance the design, conduct, analysis, and reporting of RCTs.
Our vision is to build a healthcare research ecosystem that drives meaningful, actionable improvements in clinical care. In this ecosystem:
Trials reflect real-world conditions and diverse patient populations
Methodological innovations make research efficient, cost-effective, and relevant
Health systems actively partner in generating evidence through embedded trials
Trial results are clear, actionable, and readily translated into clinical practice
Drs. Nadir Yehya and Michael Harhay received a 5-year R01 grant from NICHD to lead the PARMA trial, a study advancing treatment strategies for pediatric ARDS.
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Stay informed with the latest research findings, news, and events from CCTI.
Drs. Nadir Yehya and Michael Harhay received a 5-year R01 grant from NICHD to lead the PARMA trial, a study advancing treatment strategies for pediatric ARDS.
Penn researchers, including Drs. Halpern and Harhay, found that electronic nudges improved end-of-life care discussions in ICUs, increasing hospice discharges and comfort-care orders without shortening hospital stays.
Drs. Christie, Halpern, and Harhay are to be honored by the American Thoracic Society (ATS) for excellence in research, humanism, and mentorship. Awards will be presented at the 2025 ATS International Conference in San Francisco (May 18-21, 2025).
Michael Harhay, PhD, MPH, co-authors “Bayesian Statistics for Clinical Research” in The Lancet, comparing Bayesian and frequentist methods and highlighting the growing accessibility and impact of Bayesian analysis in medical research.
Associate Professor,
Department of Biostatistics, Epidemiology & Informatics;
Director, Center for Clinical Trials Innovation
📧 Email: mharhay@pennmedicine.upenn.edu
Office Address:
304 Blockley Hall
423 Guardian Dr.
University of Pennsylvania
Philadelphia, PA 19104-6116