Parker Wilson, MD, PhD (Pathology)
Assistant Professor of Pathology and Laboratory Medicine
Assistant Professor of Pathology and Laboratory Medicine
Member, Institute of Diabetes, Obesity and Metabolism – University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact
713B Stellar-Chance Laboratories Building
Philadelphia, PA 19104
Office: 215 746 4321
Lab: 215 746 4321
Links
Education
- BS (Engineering with a Concentration in Computer Science) Johns Hopkins University, 2005.
- MD, PhD (Molecular and Cellular Biology and Pathobiology) Medical University of South Carolina, 2013.
Selected Publications
Cheng SY, Koppitch K, Guo J, Moy N, Simonian TL, Wilson PC, McMahon AP: Nfkb1 Removal from Proximal Tubule Cells Improves Renal Tubular Outcomes Following Ischemia Reperfusion Injury. Kidney360 June 2025 Notes: Analyzed scRNA-seq datasets of mice with kidney-specific Nfkb1 knockout to show changes in proximal tubule signaling pathways.
Khan S, Zaki A, Masood M, Khan A, Mohsin M, Verma A, Wilson PC, Ali S, Syed MA: Combating sepsis-induced acute lung injury: PARP1 inhibition mediates oxidative stress mitigation and miR-135a-5p/SMAD5/Nanog axis drives regeneration. Int Immunopharmacol January 2025.
Verma A, Wilson PC: Advances in Single-Cell Sequencing and Spatial Profiling of Kidney Disease. American Journal of Pathology January 2025.
Ihara K, Satake E, Wilson PC, Krolewski B, Kobayashi H, Md Dom ZI, Ricca J, Wilson J, Dreyfuss JM, Niewczas MA, Doria A, Nelson RG, Pezzolesi MG, Humphreys BD, Duffin K, Krolewski AS: Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes. JCI Insight October 2024 Notes: Dr. Wilson conducted all of the single-cell analysis in this paper and demonstrated that the circulating proteins predictive of kidney disease progression likely originate from a specific population of injured proximal tubule cells.
Agraz JL, Agraz C, Chen AA, Rice C, Pozos RS, Aelterman S, Tan A, Viaene AN, Nasrallah MP, Sharma P, Grenko CM, Kurc T, Saltz J, Feldman MD, Akbari H, Shinohara RT, Bakas S, Wilson P: Optimized Whole-Slide-Image H&E Stain Normalization: A Step Towards Big Data Integration in Digital Pathology. IEEE Open J Eng Med Biol September 2024.
Agraz JL, Agraz C, Chen AA, Rice C, Pozos RS, Aelterman S, Tan A, Viaene AN, Nasrallah MP, Sharma P, Grenko CM, Kurc T, Saltz J, Feldman MD, Akbari H, Shinohara RT, Bakas S, Wilson P: Optimized Whole-Slide-Image H&E Stain Normalization: A Step Towards Big Data Integration in Digital Pathology. IEEE Open J Eng Med Biol September 2024.
Wallwork RS, Kotzin JJ, Cappelli LC, Mecoli C, Bingham CO 3rd, Wigley FM, Wilson PC, DiRenzo DD, Shah AA: Immune checkpoint inhibitor therapy in patients with cancer and pre-existing systemic sclerosis. Semin Arthritis Rheum May 2024 Notes: Contributed renal histology images of patients with systemic scleroderma.
Ledru N, Wilson PC, Muto Y, Yoshimura Y, Wu H, Li D, Asthana A, Tullius SG, Waikar SS, Orlando G, Humphreys BD: Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing. Nat Communications Feb 2024 Notes: Provided original analysis and mentorship for first-author to generate single-cell atlas from multiome data.
Wilson PC, Verma A, Yoshimura Y, Muto Y, Li H, Malvin NP, Dixon EE, Humphreys BD: Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease. Genome Biology January 2024 Notes: First-corresponding author. Demonstrate cell-specific loss of Y chromosome. Novel techniques for estimating the fraction of cells with loss of Y chromosome – implications for detection of somatic mosaicism in other organs.
Tarek Alhamad (Editor): Washington Manual of Transplant Pathology. Wolters Kluwer. Wolters Kluwer, October 2023 Notes: Wrote chapter on antibody-mediated rejection.