Center for Clinical Trials Innovation (CCTI)
An international research, training, and collaboration hub that will improve health through methodological advances in clinical trials.
Research Funding and Support
Grants and funders that advance CCTI’s research mission.
| Funder | Title | Grant Numbers |
|---|---|---|
| NHLBI/NIH | Advancing the design, analysis, and interpretation of acute respiratory distress syndrome trials using modern statistical tools | R01-HL168202 Project Details |
| NIA/NIH | Improving the delivery and equity of inpatient palliative care: a hybrid type I pragmatic cluster trial | R01-AG082874 Project Details |
| PCORI | Toward Improved Design and analysis of stepped wedge trials: an estimand-aligned and efficiency-focused framework | ME-2022C2-27676 Project Details |
| PCORI | Causal mediation methods for cluster-randomized pragmatic and implementation trials | ME-2023C1-31350 Project Details |
| NIA/NIH | Leveraging the electronic health record and behavioral nudges to promote primary and specialist palliative care for inpatients with serious illness: A pragmatic trial | R01-AG073384 Project Details |
| AHRQ | An equity-focused intervention to improve care transitions for Medicaid insured individuals with co-occurring serious mental health | R18-HS029815 Project Details |
| NICHD/NIH | Pediatric Acute Respiratory distress syndrome MAnagement (PARMA) Trial | R01-HD117422 Project Details |
| NIDDK/NIH | Markers of Nephrotoxicity during treatment with Antibiotic Combinations: The MONACO clinical trial | R01-DK140714 Project Details |
| NHLBI/NIH | New win methods for addressing multiple and composite outcomes in cluster-randomized trials | R01-HL178513 Project Details |
Primary Penn Collaborators
The Center for Clinical Trials Innovation is in partnership with the The Palliative and Advanced Illness Research (PAIR) Center and the Nudge Unit at the Center for Health Care Transformation & Innovation.
The PAIR Center
The Palliative and Advanced Illness Research (PAIR) Center was established in January 2017 by Dr. Scott Halpern. The center discovers novel solutions and research methods to address the complex challenges facing seriously ill patients, their care partners, clinicians, and health systems.
Within PAIR, the Clinical Trials Methods and Outcomes Lab, led by Dr. Michael Harhay, aims to improve the analysis and interpretation of randomized trial data, both for critical care and related fields specifically, and trials more generally.
The Nudge Unit
The Penn Medicine Nudge Unit is the world’s first behavioral design team embedded within a health system. The Nudge Unit is supported by the Center for Health Care Transformation and Innovation and the Penn Center for Health Incentives and Behavioral Economics.
Their mission is to design, implement, evaluate, and scale evidence-based, behaviorally informed nudges that steer decisions toward higher-value care, better patient outcomes, enhanced public health, and greater health equity.