Yanxiang Deng, PhD (Pathology)
Assistant Professor of Pathology and Laboratory Medicine
Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Department: Pathology
Contact
Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Stellar-Chance Laboratories
422 Curie Boulevard, Room 713A
Philadelphia, PA 19104
Email: Yanxiang.Deng@Pennmedicine.upenn.edu
Specialty Division
Cancer and Immunobiology
Research Expertise
Spatial omics, Single-cell analysis, Microfluidics
Graduate Groups
Cell and Molecular Biology
Genomics and Computational Biology
Education
PhD, Rensselaer Polytechnic Institute (RPI), 2018
Postgraduate Training
Postdoctoral Associate, Yale University, 2018-2022
Awards and Honors
National Scholarship, 2008
Founders Award of Excellence, Rensselaer Polytechnic Institute, 2015
Blavatnik Awards for Young Scientists, Regional Awards Laureate in Life Sciences, 2023
Memberships and Professional Organizations
Biomedical Engineering Society, 2024 – Present
Web Links
Selected Publications
Spatial profiling of chromatin accessibility in mouse and human tissues
Deng Y, Bartosovic M, Ma S, Zhang D, Liu Y, Qin X, Su G, Xu ML, Halene S, Craft JE, Castelo-Branco G, Fan R. Nature 609: 375-383, 2022. (Highlight in Nature Structural & Molecular Biology)
Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level
Deng Y, Bartosovic M, Kukanja P, Zhang D, Liu Y, Su G, Enninful A, Bai Z, Castelo-Branco G, Fan R. Science 375: 681-686, 2022.
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
Liu Y#, Yang M#, Deng Y#, Su G, Enninful A, Guo C, Tebaldi T, Zhang D, Kim D, Bai Z, Norris E, Pan A, Li J, Xiao Y, Halene S, Fan R. Cell 183: 1–17, 2020. (# Co-first author) (Highlight in Nature Methods) (Method of the Year by Nature Methods)
Single-cell omics analyses enabled by microchip technologies
Deng Y, Finck A, Fan R. Annual Review of Biomedical Engineering 21: 365–393, 2019.
Hydroporator: A hydrodynamic cell membrane perforator for high-throughput vector-free nanomaterial intracellular delivery and DNA origami biostability evaluation
Kizer M#, Deng Y#, Kang G-Y, Paiyz M, Wang X, Chung AJ. Lab on a Chip 19: 1747–1754, 2019. (# Co-first author) (Featured as cover image)
Microfluidics-enabled orientation and microstructure control of macroscopic graphene fibres
Xin G, Zhu W, Deng Y, Chung AJ, De S, Lian J. Nature Nanotechnology 14, 168–175, 2019.
Intracellular delivery of nanomaterials via an inertial microfluidic cell hydroporator
Deng Y, Kizer M, Rada M, Sage J, Wang X, Cheon DJ, Chung AJ. Nano Letters 18, 2705-2710, 2018.
Inertial microfluidic cell stretcher (iMCS): Fully automated, high-throughput, and near real-time cell mechanotyping
Deng Y, Davis SP, Yang F, Paulsen KS, Kumar M, Sinnott-DeVaux R, Wang X, Conklin DS, Oberai A, Herschkowitz JI, Chung AJ. Small 13, 1700705, 2017. (Featured as cover image)
Sub-100 micron 3D-shaped particles from next generation-optofluidic fabrication
Paulsen K, Deng Y, Chung AJ. Advanced Science 5:1800252, 2018.